Just to keep everyone in the loop, after a week of testing, preliminary results with SmithCart v4.26 and DotNetNuke 6.0 CTP2 look very promising. DotNetNuke 5.6.2 was the last vb.net/5.x version and all efforts are now on 6.0 and c#.
	 
	DNN 6.0 Major Highlights
	Core ported from VB to C#
	Popup Edit Windows
	Page Admin (via drag/drop)
	Form Patterns
	Module Branding
	Telerik ASP.net AJAX
	DDRMenu
	 
	The DNN 6 beta release is expected around the end of April.
	 
	FWIW, I have been working with DotNetNuke for 8 years (since v1) and using SmithCart since Q3 2010.